X-ray absorption spectroscopy was used to confirm a combination of Tc IV and Tc V, which is subsequently complexed into a POM defect as a Tc V=O species. Hunter College and The Graduate Center at the City University of New York. Alcohol liver disease (ALD) is a major cause of liver-related mortality globally, yet there remains an unmet demand for approved ALD drugs. Mass Spectrometry Research Unit, University College of Swansea, Singleton Park, Swansea, SA2 8PP, UK. Specifically, we report on the mechanism by which the reduction of technetium occurs and find that PW 12, SiW 12, and AlW 12 promote the reduction of TcO 4 – to lower valent states. In this work we investigate the potential of “plenary” Keggin POMs (XW 12O 40 n–) (X = P, Si, Al, n = 3, 4, 5, respectively) to both reduce TcO 4 – and stabilize the reduced Tc species. Our lab has explored this strategy using the lacunary alpha-2 Wells–Dawson polyoxometalate (α 2- 10–) to both reduce and sequester lower valent technetium, and we have reported on the ligand features that stabilize the reduced species. Zeglis, Department of Chemistry, Hunter College and the Graduate Center of the City University of New York, 413 East 69th Street, New York, NY 10021, USA. Hyperpolarized 1-13 C pyruvate can be used to examine the metabolic state of cancer cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to lactate, even in the presence of oxygen (Warburg effect). Alternative approaches have involved the reduction and subsequent sequestration of lower valent technetium species using iron, sulfides, or iron sulfides. Department of Radiology, Weill Cornell Medical College, New York, New York, USA. Most strategies for the removal of pertechnetate from the environment involve uptake and/or absorption of pertechnetate using resins, clays, cationic metal-organic frameworks and even thorium borate ceramic like materials. Technetium-99 (half-life of 2.1 × 10 5 yrs, β max = 0.29 MeV) is a hazardous radiological contaminant, which, in its predominant form of pertechnetate (TcO 4 –), is highly mobile in the environment.

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